Research projects

SEPTEMBER 2023

Hessels, L. M., Speksnijder, E., Paternotte, N., van Huisstede, A., Thijs, W., Scheer, M., van der Steen-Dieperink, M., Knarren, L., van Den Bergh, J. P., Winckers, K., Henry, R., Simsek, S., Boersma, W. G., & COVIDPredict Study Group (2023). Procalcitonin-Guided Antibiotic Prescription in Patients With COVID-19: A Multicenter Observational Cohort Study. Chest, 164(3), 596–605. https://doi.org/10.1016/j.chest.2023.04.032

SEPTEMBER 2023

Appelman, B., Michels, E. H. A., de Brabander, J., Peters-Sengers, H., van Amstel, R. B. E., Noordzij, S. M., Klarenbeek, A. M., van Linge, C. C. A., Chouchane, O., Schuurman, A. R., Reijnders, T. D. Y., Douma, R. A., Bos, L. D. J., Amsterdam UMC COVID-19 Biobank study group, CovidPredict study group, Wiersinga, W. J., & van der Poll, T. (2023). Thrombocytopenia is associated with a dysregulated host response in severe COVID-19. Thrombosis research, 229, 187–197. https://doi.org/10.1016/j.thromres.2023.07.008

Slim MA, Appelman B, Peters-Sengers H, Dongelmans DA, de Keizer NF, Schade RP, de Boer MGJ, Müller MCA, Vlaar APJ, Wiersinga WJ, van Vught LA; NICE COVID-19 Research Consortium and the COVIDPredict study group. Real-world Evidence of the Effects of Novel Treatments for COVID-19 on Mortality: A Nationwide Comparative Cohort Study of Hospitalized Patients in the First, Second, Third, and Fourth Waves in the Netherlands. Open Forum Infect Dis. 2022 Nov 22;9(12):ofac632. doi: 10.1093/ofid/ofac632. PMID: 36519114; PMCID: PMC9745783.

Mortality and readmission rates among hospitalized COVID-19 patients with varying stages of chronic kidney disease: a multicenter retrospective cohort. Appelman B, Oppelaar JJ, Broeders L, Wiersinga WJ, Peters-Sengers H, Vogt L; CovidPredict Study Group.Sci Rep. 2022 Feb 10;12(1):2258. doi: 10.1038/s41598-022-06276-7.

Treatment with a DPP-4 inhibitor at time of hospital admission for COVID-19 is not associated with improved clinical outcomes: data from the COVID-PREDICT cohort study in The Netherlands. Meijer RI, Hoekstra T, van den Oever NCG, Simsek S, van den Bergh JP, Douma RA, Reidinga AC, Moeniralam HS, Dormans T; Amsterdam UMC COVID-19 biobank study group, Smits MM.J Diabetes Metab Disord. 2021 Jun 26;20(2):1155-1160. doi: 10.1007/s40200-021-00833-z. eCollection 2021 Dec.

Pre-admission anticoagulant therapy and mortality in hospitalized COVID-19 patients: A retrospective cohort study. van Haaps TF, Collard D, van Osch FHM, Middeldorp S, Coppens M, de Kruif MD, Vlot EA, Douma RA, Ten Cate H, Juffermans NP, Gritters N, Vlaar AP, Reidinga AC, Heuvelmans MA, Oudkerk M, Büller HR, van den Bergh JPW, Maas A, Ten Wolde M, Simsek S; Corona Research Fund Amsterdam UMC, Beudel M, van Es N; Dutch COVID & Thrombosis Coalition.Thromb Res. 2021 Dec;208:35-38. doi: 10.1016/j.thromres.2021.10.006. Epub 2021 Oct 15.

Early warning scores to assess the probability of critical illness in patients with COVID-19.Veldhuis L, Ridderikhof ML, Schinkel M, van den Bergh J, Beudel M, Dormans T, Douma R, Gritters van den Oever N, de Haan L, Koopman K, de Kruif MD, Noordzij P, Reidinga A, de Ruijter W, Simsek S, Wyers C, Nanayakkara PW, Hollmann M.Emerg Med J. 2021 Dec;38(12):901-905. doi: 10.1136/emermed-2020-211054. Epub 2021 Oct 27.PMID: 34706897 

Predicting mortality of individual patients with COVID-19: a multicentre Dutch cohort. Ottenhoff MC, Ramos LA, Potters W, Janssen MLF, Hubers D, Hu S, Fridgeirsson EA, Piña-Fuentes D, Thomas R, van der Horst ICC, Herff C, Kubben P, Elbers PWG, Marquering HA, Welling M, Simsek S, de Kruif MD, Dormans T, Fleuren LM, Schinkel M, Noordzij PG, van den Bergh JP, Wyers CE, Buis DTB, Wiersinga WJ, van den Hout EHC, Reidinga AC, Rusch D, Sigaloff KCE, Douma RA, de Haan L, Gritters van den Oever NC, Rennenberg RJMW, van Wingen GA, Aries MJH, Beudel M; Dutch COVID-PREDICT research group. BMJ Open. 2021 Jul 19;11(7):e047347. doi: 10.1136/bmjopen-2020-047347.

Cardiovascular risk factors and COVID-19 outcomes in hospitalised patients: a prospective cohort study. Collard D, Nurmohamed NS, Kaiser Y, Reeskamp LF, Dormans T, Moeniralam H, Simsek S, Douma R, Eerens A, Reidinga AC, Elbers PWG, Beudel M, Vogt L, Stroes ESG, van den Born BH.BMJ Open. 2021 Feb 22;11(2):e045482. doi: 10.1136/bmjopen-2020-045482.

 Association of clinical sub-phenotypes and clinical deterioration in COVID-19: further cluster analyses.  Schinkel M, Appelman B, Butler J, Schuurman A, Wiersinga WJ; COVID Predict Study Group.Intensive Care Med. 2021 Apr;47(4):482-484. doi: 10.1007/s00134-021-06363-9. Epub 2021 Feb 18.

Cardiovascular risk factors are idependently associated with COVID-19 mortality: a prospectove cohort study Didier Collard, Nick S. Nurmohamed, Yannick Kaiser, Laurens F. Reeskamp, Tom Dormans, Hazra Moeniralam, Suat Simsek, Renée A. Douma, Annet Eerens, Auke C. Reidinga, Paul Elbers, Martijn Beudel, Liffert Vogt, Erik S.G. Stroes, Bert-Jan H. van den Born BMJ Open ahead of press 

[Clinical course of COVID-19 in the Netherlands: an overview of 2607 patients in hospital during the first wave]. Ariës MJH, van den Bergh JP, Beudel M, Boersma W, Dormans T, Douma RA, Eerens A, Elbers PWG, Fleuren LM, Gritters van den Oever NC, de Haan L, van der Horst IJCC, Hu S, Hubers D, Janssen MLF, de Kruif M, Kubben PL, van Kuijk SMJ, Noordzij PG, Ottenhoff M, Piña-Fuentes DAI, Potters WV, Reidinga AC, Renckens RSC, Rigter S, Rusch D, Schinkel M, Sigaloff KCE, Simsek S, Stassen P, Stassen R, Thomas RM, van Wingen GA, Vonk Noordegraaf A, Welling M, Wiersinga WJ, Wolvers MDJ, Wyers CE. Ned Tijdschr Geneeskd. 2021 Jan 11;165:D5085.

Outcomes of persons with coronavirus disease 2019 in hospitals with and without standard treatment with (hydroxy)chloroquine. Peters EJ, Collard D, Van Assen S, Beudel M, Bomers MK, Buijs J, De Haan LR, De Ruijter W, Douma RA, Elbers PW, Goorhuis A, Gritters van den Oever NC, Knarren LG, Moeniralam HS, Mostard RL, Quanjel MJ, Reidinga AC, Renckens R, Van Den Bergh JP, Vlasveld IN, Sikkens JJ; CovidPredict Study Group. Clin Microbiol Infect. 2021 Feb;27(2):264-268. doi: 10.1016/j.cmi.2020.10.004. Epub 2020 Oct 14.

Antihypertensive drugs in COVID-19 infection. Pinto-Sietsma SJ, Flossdorf M, Buchholz VR, Offerhaus J, Bleijendaal H, Beudel M, Volders PGA, Ter Bekke RMA, Dormans T, Zwetsloot PP, de Jager P, Massberg S, Rämer P, Wendtner C, Hoffmann E, Rothe K, Feihl S, Kessler T, Pinto YM, Schunkert H. Antihypertensive drugs in COVID-19 infection. Eur Heart J Cardiovasc Pharmacother. 2020 Nov 1;6(6):415-416. doi: 10.1093/ehjcvp/pvaa058. PMID: 32501477; PMCID: PMC7314060.

The COVID predict consortium stimulates the use of the database in participating centres in the Netherlands. The data can be used if a (1) reciprocal DSA is signed with coordinating center, (2) the research question fits with the obtained medical ethical approval (UAMC) and data protection agreement, (3) the research title and contact person is visible on the website (4) in publications grant applications the ‘COVID predict database’ is acknowledged and (5) centres are open for collaboration with other (data) centres/researchers. 

Insight into prognosis / course of COVID-19 in immune-compromised patients. Coordinating centre: UMC Utrecht, contact: dr. Paco Welsing, p.m.j.welsing@umcutrecht.nl

Mapping the incidence of pulmonary embolisms in COVID-19 patients admitted to Dutch hospitals. coordinating centre: Viecuri Medisch Centrum, contact: prof. dr. Joop van den Bergh, jvdbergh@viecuri.nl

HOLLAND: HypercOaguLabilLity And iNflammatory Dysregulation in COVID-19 infection: prognostic, diagnostic, and therapeutic implications of the inflammation-coagulation interaction in clinical practice. coordinating centre: Zuyderland Ziekenhuis, contact: dr. M. de Kruif, m.dekruif@zuyderland.nl

Use of antibiotics in COVID-19. coordinating centre: Amsterdam UMC, contact: dr. Edgar Peters, e.peters@amsterdamumc.nl

Prevalence and incidence of atrial fibrillation in proven Covid-19 patients and relationship with (duration) ICU admission, duration of admission overall, mortality.coordinating centre: Noordwest Ziekenhuisgroep, contact: dr. Suat Simsek, s.simsek@nwz.nl 

Incidence and prognosis of hyponatraemia in patients admitted with proven covid-19. coordinating centre: Flevoziekenhuis, contact: dr. Renée Douma, rdouma@flevoziekenhuis.nl

Unravelling the Different Roles of Systemic Causes of an Altered Level of Consciousness in a Cohort of COVID-19 Patients Presenting at the Emergency Department. Amsterdam UMC, contact: m.beudel@amsterdamumc.nl